行业动态

Application of SAA test in the diagnosis of COVID-19

Published:2021-09-01

Source:[英文]九强生物

Serum amyloid A (SAA) is an acute reactive protein that is synthesized by the liver during viral infection. SAA changes significantly before and after the body's inflammatory response. The transcription level of its genes can be increased to 200 times that of itself during the body's inflammatory response stage, with a shorter half-life and a lower basal concentration.And the mechanism of SAA clearance in vivo is not kidney-dependent, and it can be significantly increased within 4 hours when the body is infected, and SAA can quickly drop to normal levels after the pathogen is cleared or treated.



Serum amyloid A (SAA) is an acute reactive protein that is synthesized by the liver during viral infection. SAA changes significantly before and after the body's inflammatory response. The transcription level of its genes can be increased to 200 times that of itself during the body's inflammatory response stage, with a shorter half-life and a lower basal concentration.And the mechanism of SAA clearance in vivo is not kidney-dependent, and it can be significantly increased within 4 hours when the body is infected, and SAA can quickly drop to normal levels after the pathogen is cleared or treated.



The ROC curve of hematology index to judge CT staging

The above result suggest that SAA has great application value for early screening and auxiliary diagnosis of COVID-19.

SAA can make up for some of the limitations of nucleic acid and antibody testing in COVID-19 laboratory testing. The combined detection of multiple indicators can achieve complementary advantages, thereby minimizing missed diagnosis and misdiagnosis, making diagnosis more accurate, and making epidemic prevention and control more scientific and efficient.

BSBE's biochemical platform technology is mature, and the SAA assay kit has achieved good results in clinical applications in the past year. The clinical performance evaluation showed that the linearity range is 5-300mg/L. It has excellent performance and great advantages among products in the IVD industry.