New reagent for detection of Human Epididymis Protein 4 (HE4)-Beijing Strong Biotechnologies, Inc.

New reagent for detection of Human Epididymis Protein 4 (HE4)

Published：2021-10-20

Source：[英文]九强生物

BSBE is pleased to announce the availability of human epididymis protein 4, a new latex immunoturbidimetric assay for detection of Human Epididymis Protein 4 (HE4). HE4 belongs to the family of whey acidic 4-disulfide center (WFDC) proteins, which has suspected trypsin inhibitor properties. The HE4 gene (also known as WFDC2) located on chromosome 20q1213.1 encodes 14 homologous genes, consisting of 5 Composed of exons and 4 introns, the HE4 gene encodes a 13KD protein.BSBE is pleased to announce the availability of human epididymis protein 4, a new latex immunoturbidimetric assay for detection of Human Epididymis Protein 4 (HE4). HE4 belongs to the family of whey acidic 4-disulfide center (WFDC) proteins, which has suspected trypsin inhibitor properties. The HE4 gene (also known as WFDC2) located on chromosome 20q1213.1 encodes 14 homologous genes, consisting of 5 Composed of exons and 4 introns, the HE4 gene encodes a 13KD protein.

The HE4 test has the highest sensitivity in diagnosing ovarian cancer, especially in the early stages of the disease. The combined use of HE4 and CA125 is more accurate in predicting malignant tumors than either alone. Its sensitivity and specificity are 76% and 95%, respectively. It is reported that HE4 is expressed in normal tissues of respiratory tract epithelial cells and germ cells. Although there is no tissue specificity, a large number of chip studies have confirmed that HE4 is one of the most effective markers of ovarian cancer. This item cannot be used as an indicator for ovarian cancer screening.

The HE4 in the sample reacts with the hypersensitized human epididymal protein 4 antibody latex particle reagent to form an immune complex. The change in absorbance is detected at a wavelength of 660nm, and the degree of change is proportional to the content of HE4 in the sample .

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