Ischemia modified albumin
Method: Albumin-cobalt Binding Liquid reagent, R1: R2=3:1
CLINICAL SIGNIFICANCE
Ischemia modified albumin is produced when N-terminal amino acid of albumin is modified by copper ion or others. This situation occurs when a tissue is ischemia or reperfusion occurs. IMA is a early warning indicator before cell necrosis occurs in myocardical ischemia.The elevation degree can indicate the degree of myocardical ischemia. In clinic, IMA is a potential use in early diagnosis for acute myocardic ischemia(AMI) and acute coronary syndromes(ACS).
PRECISION
|
Inter assay precision-level 1 |
|||
|
N=5 |
Batch 1 |
Batch 2 |
Batch 3 |
|
Mean(IU/ml) |
48.8 |
47.8 |
49.3 |
|
|
48.6 |
||
|
(Xmax-Xmin)/ |
3.04 |
||
|
Intra assay precision |
||
|
N=20 |
level 1 |
level 2 |
|
Mean(IU/ml) |
49.7 |
83.1 |
|
SD |
0.44 |
0.41 |
|
CV(%) |
0.89 |
0.50 |
|
Inter assay precision-level 2 |
|||
|
N=5 |
Batch 1 |
Batch 2 |
Batch 3 |
|
Mean(IU/ml) |
83.9 |
82.8 |
85.6 |
|
|
84.1 |
||
|
(Xmax-Xmin)/ |
3.35% |
||
Sensitivity
When the sample concentration is 78U/ml, the change of absorbance should not be more than 0.1500.
Correlation
The correlation of a well-known brand(X) and Gcell(Y) is y= 0.9958x +0.7786,R2=0.9370
Interference
|
Analytes |
Concentration |
|
Bilirubin |
40 mg/dl |
|
Hemoglobin |
200 mg/dl |
|
Intralipid |
600 mg/dl |
|
VC |
50mg/dl |
|
Heparin |
100U/ml |
Linearity
Linearity is up to 100 U/mL.